PSEUDOMONAS AERUGINOSA

·         Pseudomonas aeruginosa is gram negative bacteria . its is also aerobic bacteria.

·         Pseudomonas mostly present in any moist location.

·         It is a common cause of nosochomial infections. Nosochomial ifections are those infections which are acquired through hospitals or other family care facility. They are spread thorugh various means.

·         Pseudomonas aeruginosa is also an oppertunistic pathogen . oppertunistic pathogens infects the person when oppertunity is available like patient have weakend  immune system . they are not harmfull normally.(Monica2000)

1.6.1:Pseudomonas aeruginosa infections:

·         They mostly concern with cystic fibrosis , burn patients and hospitilized patients.

·         Mortaility rate of case is approches to 50%.

·         Cystic fibrosis is most common life threating disease. it is caused by the inherited genetic disorder.

·         One in every 25 carries the mutated recessive gene.

·         More than 1 in 4000 live births suffers from cystic fibrosis.

·         Cystic fibrosis affects number of body organs.  Cycle of infection leads to progressive deterioration of lung function.(Monica2000)

1.6.2:Patho mechanism:

·         Pathogenesis starts from adhesion by means of flagella, pili, fimbriae.

·         Extracellular enzymes and toxins help for its invasion.

·         Leuckocidin help it to prevent itself from leukocytes and neutrophills.

·         LPS exotoxin also prevent from immune system.

·         Protection is also carried out by capsule.

1.6.3: Treatment:

·         P.aeruginosa resistant to many commonly used antibiotics but combination of gentamicin and carbeniciilin are frequently used for its treatment.

·         There is vaccine discovered for pseudomonas so far.

(Monica2000)